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[目的]评价胃癌手术患者术中腹腔放置铜绿假单胞菌制剂的安全性及对免疫功能的影响。[方法]72例进展期胃癌患者随机分为铜绿假单胞菌制剂腹腔置药组(实验组)和对照组,实验组术毕于原手术部位按0.08～0.12ml/kg放置铜绿假单胞菌注射液,对照组予以单纯手术。全部病例均在术前及术后10、20、30d采集外周静脉血分别测定血常规、肝肾功能,CD19(B细胞)计数水平,免疫球蛋白水平(IgA、IgM和IgG),并观察患者围手术期并发症及不良反应。[结果]实验组围手术期血常规、肝肾功能均在正常值范围内。术后30d,实验组较对照组IgA(P=0.037)、IgG(P=0.044)及CD19计数水平(P=0.043)明显提高。实验组术后10d IgM较术前明显增高(P=0.011)。两组均未出现明显不良反应。[结论]铜绿假单胞菌制剂胃癌术中腹腔给药安全可行,可增强机体体液免疫调节作用。
[Objective] To evaluate the safety and immunologic function of Pseudomonas aeruginosa intraperitoneal in patients with gastric cancer surgery. [Method] 72 patients with advanced gastric cancer were randomly divided into Pseudomonas aeruginosa intraperitoneal injection group (experimental group) and control group, the experimental group completed the operation at the site of 0.08 ~ 0.12ml / kg placed Pseudomonas aeruginosa Bacteria injection, the control group to be simple surgery. Peripheral venous blood was collected before operation and at 10, 20 and 30 days after operation. Blood routine, liver and kidney function, CD19 (B cell) count, IgA, IgM and IgG were measured in all cases. Perioperative complications and adverse reactions. [Results] The perioperative blood routine, liver and kidney function in the experimental group were within the normal range. The level of IgA (P = 0.037), IgG (P = 0.044) and the level of CD19 (P = 0.043) in experimental group were significantly higher than those in control group on the 30th day after operation. IgM in experimental group was significantly higher than preoperative 10d after operation (P = 0.011). No significant adverse reactions occurred in both groups. [Conclusion] Pseudomonas aeruginosa preparation for gastric cancer intraperitoneal administration safe and feasible, can enhance the body’s humoral immune regulation.