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自1931年McJunkin和Breuhaus首先证实肝部分切除(PH)后的鼠肝匀浆可促进肝细胞增殖以来,先后发现了不少调节肝细胞再生的物质.有的理化性质已明确,如胰岛素、胰高血糖素;有的虽经部分纯化,但性质仍未确定,如肝细胞生长因子和抑制因子,它们可能通过刺激和/或抑制作用,共同控制肝细胞的生长.对于这些因子的研究,不仅有助于了解肝损伤后肝细胞再生的机理,而且对探讨致癌过程中细胞增殖的控制与失控有重要意义,并可为探索肝病的治疗开拓新的途径.激素在肝细胞再生中的作用血液中至少有6种激素可促进肝细胞的再
Since McJunkin and Breuhaus first demonstrated in 1931 that mouse liver homogenates after partial hepatectomy (PH) can promote the proliferation of hepatocytes, many substances that regulate the regeneration of liver cells have been discovered in succession. Some physical and chemical properties have been clarified, such as insulin, pancreatic Some, though partially purified, have not yet been characterized in their nature, such as hepatocyte growth factor and inhibitory factors, which together may control the growth of hepatocytes through stimulation and / or inhibition.Research on these factors not only Help to understand the mechanism of liver cell regeneration after liver injury, but also to explore the control of cancer cells in the process of cell proliferation and loss of control is important, and explore new ways for the treatment of liver disease.Hormone in the role of liver regeneration Blood In at least six hormones can promote the re-liver cells