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目的比较顺铂+紫杉醇/顺铂+5-氟尿嘧啶方案化疗联合三维适形放疗对食管癌患者的临床疗效,以及治疗的安全性.方法本研究就140例Ⅱ/Ⅲ食管癌患者进行分组,甲组(治疗组)进行顺铂+紫杉醇方案化疗联合三维适形放疗,共76例；乙组(对照组)名进行顺铂+5-氟尿嘧啶方案化疗联合三维适形放疗,共64例.结果1 a局部控制率来看,甲组为91.8%,乙组为89.4%,差异不明显；就总生存率来看,甲组为86.1%,乙组为77.2%,有较明显差异.甲/乙两组Ⅲ度以上放射性食管炎发生率分别是28.9%/48.4%,Ⅲ度以上骨髓抑制发生率分别是69.7%/51.6%,对比具统计学意义.结论甲组疗效比乙组疗效更佳,顺铂+紫杉醇方案联合三维适形放疗能够有效地延长食管癌患者的生存期,提高其生存质量.“,”Compare the clinical efficacy and safety of cisplatin+Paclitaxel and cisplatin+5-fluorouracil which combined with three dimensional conformal radiotherapy treatment for patients with esophageal carcinoma.Methods In this study,divide 140ⅡandⅢesophageal cancer into two groups,Group A of 76 (treatment group)which were given cisplatin+paclitaxel chemotherapy combined with three-dimensional conformal radiotherapy,and group B of 64 (control group)which were performed with cisplatin+5-fluorouracil chemotherapy combined with three-dimensional conformal radiotherapy.Results On the local control rate 1 a,the Group A was 91.8%,group B was 89.4%,and the difference was not statistically significant.On overall survival,the Group A was 86.1%,Group B 77.2%,the difference is of statistically significant.The incidence of radiation esophagitis aboveⅢdegrees of A and B groups were 28.9%,48.4%,the incidence of bone marrow suppression aboveⅢdegrees were 69.7%,51.6%.The difference is of statistically significant.Conclusion Treatment of group A was more efficacy than group B.Cisplatin and paclitaxel chemotherapy combined with three-dimensional conformal radiation therapy can effectively prolong survival of patients with esophageal cancer and improve their quality of life.