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目的 :观察替硝唑栓体内外抗阴道毛滴虫作用。方法 :经临床分离阴道毛滴虫 3 5株 ,观察替硝唑栓体外抗阴道毛滴虫作用 ;临床阴道滴虫病病人 75例用替硝唑栓 ( 0 .1g/粒 )治疗 ,隔日晚上睡时放入阴道 1粒 ,疗程 3d ,观察替硝唑栓体内抗阴道毛滴虫作用。选用甲硝唑栓作对照。结果 :替硝唑栓体外对阴道毛滴虫最小致死浓度为3 .72± 1 .2 4 μg/ml;替硝唑栓对临床阴道滴虫病治疗有效率 89% ,滴虫转阴率 99% ,与甲硝唑栓作用相似。 结论 :替硝唑栓体内外抗阴道滴虫作用与甲硝栓相似 ,但体内治疗替硝唑栓疗程比甲硝唑栓缩短。
Objective: To observe the effect of tinidazole suppository on Trichomonas vaginalis in vitro and in vivo. Methods: Clinical isolates of Trichomonas vaginalis 35 were observed tinidazole in vitro against Trichomonas vaginalis role; clinical vaginal trichomoniasis patients with tinidazole suppository (0.1g / tablets) treatment, the next night Sleep into the vagina 1, course of treatment 3d, tinidazole suppository to observe the role of Trichomonas vaginalis. Metronidazole suppository for the control. Results: The minimum lethal concentration of tinidazole plug to Trichomonas vaginalis was 3.72 ± 1.24 μg / ml. The effective rate of tinidazole suppository for treating clinical vaginal trichomoniasis was 89%, and that of trichomoniasis was 99 %, And metronidazole suppository similar. Conclusion: The effect of tinidazole suppository against Trichomonas vaginalis is similar to that of Metronidazole, but the treatment of tinidazole suppository in vivo is shorter than that of Metronidazole suppository.