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目的研究产超广谱β-内酰胺酶(ESBLs)的革兰氏阴性菌引起的医院感染发生率,为临床防治对策提供依据。方法调查了2002年5月～2003年1月间由产ESBLs革兰阴性菌引起的医院感染。结果产ESBLs革兰阴性菌的医院感染细菌多见于肺炎克雷伯菌,占60%,其次为大肠埃希菌,约占30%。调查发现,此感染多见于那些ICU病房的危重病人及机体抵抗力差的患者中,并与长期住院和应用广谱抗生素有明显关系。结论产ESBLs革兰阴性在医院中的感染正日益增多,尤其多见于长期住院、应用广谱抗生素、住ICU病房的患者中;亚胺培南是目前治疗产ESBLs菌感染最有效药物之一。
Objective To study the incidence of nosocomial infections caused by Gram-negative bacteria producing extended-spectrum β-lactamases (ESBLs) and provide the basis for clinical prevention and treatment. Methods A nosocomial infection caused by gram-negative ESBLs-producing bacteria was investigated between May 2002 and January 2003. Results The nosocomial bacteria producing ESBLs-Gram-negative bacteria were more common in Klebsiella pneumoniae, accounting for 60%, followed by Escherichia coli, accounting for about 30%. The survey found that this infection more common in those critically ill ICU wards and patients with poor body resistance and long-term hospitalization and the application of broad-spectrum antibiotics have a clear relationship. Conclusions Gram-negative ESBLs-producing infections in hospitals are increasing, especially in long-term hospitalized patients with broad-spectrum antibiotics who live in ICU wards. Imipenem is currently one of the most effective drugs for the treatment of ESBLs-producing bacterial infections.