论文部分内容阅读
采用中国药典1995年版中头孢哌酮的流动相对头孢唑啉进行测定,样品峰与内标峰的分离度为5.64,多次进样的RSD为0.79％。 头孢唑啉和头孢哌酮均为临床常用药,也是日常检验经常检测的两种抗生素,中国药典1995年版中收载的这两个品种的含量测定方法均为高效液相色谱法,但流动相的选择有所不同,检验中我们试用头孢哌酮的流动相对头孢唑啉进行检测,结果良好,样品峰与内标峰的分离度为5.64,多次进样的RSD为0.79％,而中国药典的1995年版中头孢唑啉的含量测定要求样品峰与内标峰的分离度为4.0,多次进样的RSD为2.0％,该方法均达到药典要求。
The cefazolin was determined by the flow of cefoperazone in Chinese Pharmacopoeia (1995 edition). The separation of peak and internal standard peak was 5.64 and the RSD of multiple injection was 0.79%. Cefazolin and cefoperazone are commonly used in clinical medicine, but also routine testing of two antibiotics often tested, Chinese Pharmacopoeia 1995 edition contained in the determination of the contents of these two varieties are high performance liquid chromatography, but the mobile phase The test results showed that cefoperazone flow rate was higher than that of cefazolin test, and the result was good. The separation of sample peak from internal standard peak was 5.64, RSD of multiple injection was 0.79%, while Chinese Pharmacopoeia The 1995 edition of cefazolin content determination requires sample peak and internal standard peak resolution of 4.0, multiple injection RSD of 2.0%, the method meets the pharmacopoeia requirements.