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目的：在体研究不同剂量（０．５、１、５、８ｇ·ｋｇ－１）的云芝糖肽（ＰＳＰ）对小鼠的痛阈、耐力和免疫功能的影响。方法：用不同剂量的ＰＳＰ给小鼠连续７ｄ灌胃之后，测定其痛阈（热板法）、游泳耐力和Ｔ淋巴细胞增殖。结果：１ｇ·ｋｇ－１剂量的ＰＳＰ连续灌胃能显著地提高痛阈，显著地增强游泳耐力，但对Ｔ淋巴细胞增殖未见明显影响。大剂量（５～８ｇ·ｋｇ－１）的ＰＳＰ连续灌胃，不仅不能进一步提高镇痛效应和游泳耐力，相反，镇痛效应、耐力和Ｔ淋巴细胞增殖都有所下降。结论：５～８ｇ·ｋｇ－１大剂量ＰＳＰ的长期应用，有可能给正常小鼠带来负面影响。
OBJECTIVE: To study the effects of different doses (0.5, 1, 5, and 8 g·kg-1) of PSK on the pain threshold, endurance, and immune function in mice. METHODS: Following a 7-day gavage of mice with different doses of PSP, their pain threshold (hot plate method), swimming endurance, and proliferation of T lymphocytes were measured. RESULTS: Continuous gavage of 1 g·kg-1 dose of PSP significantly increased the pain threshold and significantly increased swimming endurance, but had no significant effect on the proliferation of T lymphocytes. Continuous administration of large doses of PSP (5-8 g·kg-1) could not only increase the analgesic effect and swimming endurance, but also decreased the analgesic effect, endurance, and proliferation of T lymphocytes. Conclusion: Long-term use of large doses of 5-8 g·kg-1 of PSP may negatively affect normal mice.