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目的:探讨小剂量阿克拉霉素、阿糖胞苷和重组人粒细胞集落刺激因子组成的GAA化疗方案治疗老年人急性髓系白血病的疗效和不良反应。方法:老年急性髓系白血病初治20例,采用CAA2周期化疗。结果:CR10例,PR5例,NR3例;死亡2例,总有效率75%。结论:小剂量GAA方案对不能耐受强化治疗的老年AML患者,尤其在骨髓增生低下者,在诱导缓解治疗方面具有一定优势。
Objective: To investigate the efficacy and adverse reactions of low dose aclacinomycin, cytarabine and recombinant human granulocyte colony stimulating factor (GAA) regimen in the treatment of acute myeloid leukemia in the elderly. Methods: 20 cases of primary acute myeloid leukemia were treated with CAA2 cycle chemotherapy. Results: CR10 cases, PR5 cases, NR3 cases; 2 cases died, the total effective rate was 75%. CONCLUSIONS: The low dose GAA regimen has some advantages in the induction of remission therapy in elderly AML patients who can not tolerate intensive treatment, especially in patients with poor myelosuppression.