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本文旨在综述蛋白结合对抗微生物药物的药物代谢动力学的影响及其临床意义。影响抗微生物药物与血清蛋白结合的因素与血清蛋白结合的抗微生物药物,主要是与血清白蛋白形成一种可逆性结合键。有些抗菌素也能与其它血清蛋白结合,但程度较小。
This article aims to review the effects of protein binding on the pharmacokinetics of antimicrobials and their clinical implications. Factors that influence the binding of antimicrobial drugs to serum proteins Anti-microbial drugs that bind to serum proteins, primarily to form a reversible bond with serum albumin. Some antibiotics also bind to other serum proteins to a lesser extent.