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目的探讨沙培林在食管癌手术中局部应用的临床效果。方法82例食管癌手术患者随机分为两组,观察组42例术中使用含有沙培林溶液的明胶海绵贴于手术创面,对照组40例术中不予沙培林处理,统计术后3 d的体温变化、胸腔引流量以及术后局部复发率。结果观察组患者术后3 d的高热发生率显著高于对照组(P<0.05),观察组术后3 d的胸腔引流量显著少于对照组(P<0.05),观察组的术后局部复发率显著低于对照组(P<0.05)。结论食管癌手术中局部应用沙培林可以有效降低局部复发率,减少胸腔引流量,值得临床推广应用。
Objective To investigate the clinical effect of topical application of sapirin in esophageal cancer surgery. Methods 82 cases of esophageal cancer surgery were randomly divided into two groups. In the observation group, 42 cases were treated with gelatin sponge containing sappaphin solution in the operation wound, 40 cases in the control group were not treated with saperilin, d changes in body temperature, chest drainage and postoperative local recurrence rate. Results The incidence of hyperthermia in the observation group was significantly higher than that in the control group 3 days after operation (P <0.05). The drainage volume of the thoracic cavity in the observation group 3 days after operation was significantly less than that of the control group (P <0.05) The recurrence rate was significantly lower than the control group (P <0.05). Conclusion Local application of sapirin in esophageal cancer surgery can effectively reduce the local recurrence rate and reduce the amount of chest drainage, which is worthy of clinical application.