Anti-inlfammatory and antipyretic properties of kang 601 heji, a traditional Chinese medicine oral l

• 作 者: Raphael Nammahime Alolga Sarah Wambui Amadi Vitus Onoja Assogba Gabin Assanhou Moses Muyaba Said Abasse Kassim
• 机 构: State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 Tongjiaxiang, Nan
• 出 处: 亚太热带生物医学杂志（英文版）
• 发表日期: 2015年11期
• 关键词: Kang 601 heji Anti-inflammatory Antipyretic Model Mechanisms

Objective:To evaluate the scientific basis for the use of Kang 601 heji (K-601) as an anti-inflammatory and antipyretic agent using appropriate animal models.
Methods:Carrageenan-induced rat paw and xylene-induced ear oedemas were models used to investigate anti-inflammatory actions of K-601. Lipopolysaccharide-induced pyrexia model was used to evaluate antipyretic activity in Wistar rats. The anti-inflammatory and antipyretic mechanisms were evaluated by detecting prostaglandins E2, nitric oxide, interleukin-1βand tumor necrosis factor-αlevels using appropriate reagents and ELISA kits.
Results:The results revealed that K-601 reduced the level of inflammations in both anti-inflammatory models in a dose-dependent manner. The same was true for the antipyretic model. The possible mechanisms of actions were through the inhibition of prostaglandins E2, interleukin-1β, tumor necrosis factor-αand nitric oxide.
Conclusions: K-601 has proven anti-inflammatory and antipyretic actions. The findings provide a scientific basis for the use of K-601 as anti-inflammatory and antipyretic agent in traditional Chinese medicinal practice.