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[目的]探讨Gal-3蛋白在结直肠癌中的表达及临床意义。[方法]采用免疫组织化学SP法检测Gal-3蛋白在60例结直肠癌组织的表达;另取癌旁正常黏膜20例及结直肠腺瘤20例作为对照组。[结果 ]结直肠癌中Gal-3蛋白的表达明显高于癌旁正常黏膜和结直肠腺瘤(55.0%,10.0%和25.0%,P<0.05)。Gal-3蛋白在侵及浆膜外、TNMⅢ+Ⅳ期、有淋巴结转移组中的表达明显高于未侵及浆膜外(P<0.05)、TNMⅠ+Ⅱ期(P<0.01)、无淋巴结转移组(P<0.05);与年龄、性别、肿瘤大小和分化程度无关。Gal-3蛋白阳性表达患者5年生存率明显低于阴性表达者(P<0.05)。[结论]Gal-3蛋白在结直肠癌中高表达,其可能在结直肠癌的发生发展和浸润转移中起作用,并提示预后不良。
[Objective] To investigate the expression of Gal-3 protein in colorectal cancer and its clinical significance. [Method] Immunohistochemical SP method was used to detect the expression of Gal-3 protein in 60 cases of colorectal cancer tissues; 20 cases of adjacent normal mucosa and 20 cases of colorectal adenoma were taken as control group. [Results] The expression of Gal-3 protein in colorectal cancer was significantly higher than that in adjacent normal mucosa and colorectal adenoma (55.0%, 10.0% and 25.0%, P <0.05). The expression of Gal-3 in TNMⅢ + Ⅳ stage and lymph node metastasis group was significantly higher than that in non-invasion and extravasation stage (P <0.05), TNMⅠ + Ⅱ stage (P <0.01), without lymph node metastasis Metastasis group (P <0.05), but not with age, sex, tumor size and differentiation degree. The 5-year survival rate of patients with Gal-3 protein expression was significantly lower than that of patients with negative expression (P <0.05). [Conclusion] The overexpression of Gal-3 protein in colorectal cancer may play a role in the carcinogenesis and invasion and metastasis of colorectal cancer, suggesting that the prognosis is poor.