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目的 研究MDM2基因与国人骨肉瘤和脂肪肉瘤的关系从而了解MDM2基因在肉瘤发生中的作用及其临床意义。方法 用免疫组化方法研究了31例骨肉瘤,2例骨旁骨肉瘤,6例软骨肉瘤,14例脂肪肉瘤MDM2的表达。结果 31例骨肉瘤中MDM2阳性表达者18例,为58.6％,骨旁骨肉瘤2例皆为阳性表达,6例软骨肉瘤中2例阳性表达;14例脂肪肉瘤中8例阳性表达,为57.1％。结论 MDM2癌基因异常与肉瘤的发生关系密切,但对肉瘤的恶性级别和预后的影响仍不明确,有待讲一步研究。
Objective To study the relationship between MDM2 gene and osteosarcoma and liposarcoma in Chinese patients to understand the role and clinical significance of MDM2 gene in sarcoma. Methods Immunohistochemistry was used to study 31 cases of osteosarcoma, 2 cases of parasellar osteosarcoma, 6 cases of chondrosarcoma, and 14 cases of liposarcoma MDM2. Results In 31 cases of osteosarcoma, 18 cases of MDM2 were positive expression, which was 58.6%. 2 cases of paraosseous osteosarcoma were positive expression, 2 cases of chondrosarcoma were positively expressed in 2 cases; 4 cases of liposarcoma were positive expression in 5 cases, 57.1 %. Conclusion The abnormality of MDM2 oncogene is closely related to the occurrence of sarcoma, but the effect on the malignant grade and prognosis of sarcoma remains unclear.