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有人报导,吸烟者帕金森氏征的发生率比不吸烟者低。由此提出这样的假说,吸烟能防止巴金森氏征临床症状的产生。帕金森氏征和迟发性运动障碍(TD)的病理生理机制相反,帕金森氏征时,纹状体多巴胺(DA)功能降低,而患TD时纹状体DA功能增强。如果吸烟可以抗帕金森氏征,那么吸烟就会促使TD的发生和加重DA的症状。本研究中,作者调查了吸烟(接触尼古丁)和TD间的关系及吸烟与安定剂的关系。方法和结果:调查对象为40岁以上,根据DSM-Ⅲ标准诊断为精神分裂症或情感障碍者,有吸烟习惯和锥体外系症状,有器质性精神障碍者及调查前6个月内已停止吸烟者除外,TD症状按0～5评定,5分为重
It has been reported that the incidence of Parkinson’s smokers is lower in smokers than in non-smokers. This led to the hypothesis that smoking prevents the onset of clinical symptoms in Parkinson’s disease. In contrast, the pathophysiological mechanisms of Parkinson’s disease and tardive dyskinesia (TD) are opposite. In Parkinson’s disease, striatum dopamine (DA) function is reduced, whereas striatal DA function is enhanced in patients with Parkinson’s disease. If smoking can be anti-Parkinson’s sign, then smoking will promote the occurrence of TD and aggravate the symptoms of DA. In this study, the authors investigated the relationship between smoking (exposure to nicotine) and TD and the relationship between smoking and tranquillizers. Methods and Results: The subjects were over 40 years of age, diagnosed as schizophrenia or affective disorder according to the DSM-Ⅲ standard, smoking habits and extrapyramidal symptoms, with organic mental disorders and within 6 months before the survey Excluding those who stopped smoking, symptoms of TD according to 0 ~ 5 assessment, 5 points for weight