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白血病干细胞(LSCs)是存在于白血病患者体内极少数具有自我更新和增殖能力的细胞,是白血病复发的根源。其具有自身独特的生物学性质,如某些特殊的细胞表面标志,及其自身的细胞周期特点。近年来,许多学者对LSCs的靶向治疗策略进行了探索,为彻底清除LSCs、达到临床长期稳定缓解提供了新的方向。蛋白质组是指细胞或组织基因组所表达的全部蛋白质。近年来,蛋白质组技术发展迅速,激光捕获微切割、蛋白质芯片等新技术促进了蛋白质组学的发展。运用蛋白质组学分析技术阐明蛋白质表达水平的变化与白血病发生发展的一些相互关系及规律,可以为进一步寻找新药和预后判断提供理论依据。现将蛋白质组学在LSCs中的研究进展综述如下。
Leukemic stem cells (LSCs) are a rare source of self-renewing and proliferative cells present in leukemia patients and are the source of leukemia relapse. It has its own unique biological properties, such as some special cell surface markers, and its own cell cycle characteristics. In recent years, many scholars have explored the targeted therapy strategy of LSCs, which provides a new direction for the complete removal of LSCs and long-term stable clinical remission. Proteome refers to the entire protein expressed by a cell or tissue genome. In recent years, rapid progress has been made in proteome technology, and new technologies such as laser capture microdissection and protein chips have promoted the development of proteomics. Using proteomics analysis techniques to elucidate the relationship between the changes of protein expression levels and the development and progression of leukemia may provide a theoretical basis for further searching for new drugs and prognosis. The research progress of proteomics in LSCs is summarized as follows.