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目的探讨2型糖尿病(T2DM)患者血小板参数变化以及血小板中基质金属蛋白酶(MMPs)的表达及意义。方法检测54例T2DM患者(A组)和46例健康人(B组)血小板计数、血小板平均体积(MPV)和血小板分布宽度(PDW),采用RT-PCR检测两组血小板中MMP-2、MMP-3和MMP-9基因的相对表达量。结果A组MPV和PDW大于B组(P<0.05)。A组血小板中MMP-2、MMP-3和MMP-9相对表达量均高于B组(P<0.01)。结论 MPV和PDW可作为监测早期糖尿病血小板功能异常的指标。血小板中MMP-2、MMP-3和MMP-9表达量可能在评价血小板参与糖尿病血管并发症中有重要意义。
Objective To investigate the changes of platelet parameters and the expression of matrix metalloproteinases (MMPs) in type 2 diabetes mellitus (T2DM) patients and their significance. Methods Platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) were measured in 54 patients with T2DM (group A) and 46 healthy subjects (group B). The levels of MMP- -3 and MMP-9 gene relative expression levels. Results The MPV and PDW in group A were greater than those in group B (P <0.05). The relative expression of MMP-2, MMP-3 and MMP-9 in group A was higher than that in group B (P <0.01). Conclusion MPV and PDW can be used as indicators to monitor early diabetic platelet dysfunction. The expression of MMP-2, MMP-3 and MMP-9 in platelets may play an important role in evaluating platelet involvement in diabetic vascular complications.