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目的探讨辅助生殖技术对新生儿先天性甲状腺功能低下症的影响,为今后的辅助生殖技术安全性研究提供依据。方法将2009年～2011年江西省经ART助孕出生的新生儿3444例归列为研究组、同期自然受孕出生的新生儿555513例列为对照组,比较两组的TSH水平及CH发病率。结果研究组的TSH值≥8.2 mIU/L占99.34%,与对照组(99.31%)相比无统计学意义(P>0.05);研究组CH发病率为1/1722,与对照组CH发病率(1/1710)相比无统计学意义(P>0.05)。结论 ART助孕的新生儿与自然受孕的新生儿TSH水平无明显差异,CH发病率也无明显差异,近期评估辅助生殖技术是安全的。
Objective To investigate the effect of assisted reproductive technology on congenital hypothyroidism in newborns and to provide evidence for the safety of assisted reproductive technology in the future. Methods A total of 3444 newborn infants born in ART during pregnancy in Jiangxi Province from 2009 to 2011 were included in the study group. 555,513 newborns born during natural pregnancy were enrolled as control group. TSH levels and incidence of CH were compared between the two groups. Results The TSH value of the study group was ≥8.2 mIU / L, accounting for 99.34%, which was not significantly different from that of the control group (99.31%) (P> 0.05). The CH incidence of the study group was 1/1722, (1/1710) compared with no statistical significance (P> 0.05). Conclusion There is no significant difference in the TSH level between ART-assisted newborns and those who conceive naturally. The incidence of CH is also no significant difference. The recent assessment of assisted reproductive technology is safe.