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探讨了短时间－６°卧床模拟失重对外周血Ｔ淋巴细胞受到多克隆刺激剂植物凝集素（ｐｈｙｔｏｈｅｍａｇｇｌｕｔｉｎｉｎ，ＰＨＡ）刺激后增殖能力和细胞因子产生的影响。结果表明：卧床模拟失重２ｄ后Ｔ淋巴细胞受到ＰＨＡ刺激后增殖明显下降；白细胞介素－２（ｉｎｔｅｒｌｅｕｋｉｎ－２，ＩＬ－２）的活性呈下降趋势；白细胞介素－２受体（ｉｎｔｅｒｌｅｕｋｉｎ－２ｒｅｃｅｐｔｉｒ，ＩＬ－２Ｒ）的表达无明显改变；白细胞介素－６的产生明显下降。卧床模拟失重６ｄ后，淋巴细胞增殖恢复正常；ＩＬ－２的活性和ＩＬ－２Ｒ的表达无明显改变。白细胞介素－６的产生明显下降。提示：－６°卧床导致Ｔ淋巴细胞功能下降可能与其分泌的细胞因子产生减少有关
To investigate the effect of short-term 6-bed simulated weightlessness on proliferation and cytokine production of peripheral blood T lymphocytes stimulated by polyclonal stimulator phytohemagglutinin (PHA). The results showed that the proliferation of T lymphocytes was significantly decreased after PHD stimulation for 2 days, and the activity of interleukin-2 (IL-2) was decreased. The interleukin-2 susceptibility , IL-2R) expression did not change significantly; interleukin-6 production decreased significantly. After 6 days of bedridden simulated weightlessness, the proliferation of lymphocytes returned to normal; the activity of IL-2 and the expression of IL-2R did not change significantly. Interleukin-6 production was significantly reduced. Tip: -6 ° bed rest leading to decreased T lymphocyte function may be related to its secretion of cytokines decreased