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41只年龄为8周的雌性Wistar鼠，其中33只于房肿间区皮下植入直径4mm．厚lmm圆形的羟基磷灰石材料，8只为对照组。按时间分为长期和短期2组．短期组于植入后1、3、7、14天处死。长期组分别于植入后1、3、6或10月处死。手术均在无菌条件下进行。将植入材料和周围组织整块取下，经
Forty-one female Wistar rats, 8 weeks old, 33 were subcutaneously implanted 4 mm in diameter in the intercalary space. Thick lmm round hydroxyapatite material, 8 for the control group. Divided by time into long-term and short-term 2 groups. The short-term group was sacrificed on days 1, 3, 7, and 14 after implantation. Long-term groups were sacrificed at 1, 3, 6 or 10 months after implantation. Surgery was performed under sterile conditions. The implant material and the surrounding tissue removed whole, after