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以往认为低钾性周期性麻痹发作可能系因钾从血清进入肌肉细胞内所致。其后又认为该病的发生是由于肌肉的功能障碍。从测定肌纤维的平均静息夸膜电位中可看出,无论高钾性麻痹患者,或低钾性麻痹患者,均存在肌纤维膜极化不全现象,故认为血清钾本身的改变并不是引起肌无力发作的主要因素,而主要发病原因可能在于肌纤维膜的功能紊乱。Griggs等发现醋唑磺胺(Acetazolamide)对低钾性周期性麻痹治疗有效,他们治疗了用其他治疗方法无效的10例患者
In the past that episodes of hypokalemic periodic paralysis may be due to potassium into the muscle cells from the serum caused. Later that the disease is due to muscle dysfunction. Judging from the average resting quasi- membrane potential measurement of muscle fibers can be seen, regardless of patients with hyperkalemia, or hypokalemic paralysis, there are defects in the phenomenon of muscle fiber membrane, it is thought that the change in serum potassium itself is not caused by muscle weakness The main factor of attack, but the main reason may be the incidence of muscle fiber dysfunction. Griggs et al found that Acetazolamide was effective in treating hypokalemic periodic paralysis and that they treated 10 patients who were ineffective with other therapies