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目的 :探讨超氧化物歧化酶 (SOD)在肾病变的发病机理及保护作用。方法 :制造阿霉素(ADR)大鼠肾病模型 ,测定 SOD活性及相关生化指标 ,并给予 SOD治疗。结果 :ADR组红细胞SOD及血浆蛋白浓度明显低于正常对照组 ,SOD治疗后 2 4 h尿蛋白定量及相应生化指标均有明显改善。结论 :SOD有助于防治并改变微小病变型肾病变的病程
Objective: To investigate the pathogenesis and protective effect of superoxide dismutase (SOD) on nephropathy. Methods: The rat model of adriamycin (ADR) was established. The SOD activity and related biochemical indexes were determined and treated with SOD. Results: The erythrocyte superoxide dismutase (SOD) and plasma protein concentration (ADP) in ADR group were significantly lower than those in normal control group. The proteinuria and corresponding biochemical indexes of 24 h after SOD treatment were significantly improved. Conclusion: SOD helps to prevent and change the course of minimal pathological nephropathy