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阿尔兹海默病发病机制尚未阐明,目前临床上使用的药物均只能针对相应症状,不能逆转病情的发展进程,故采用新的治疗策略对阿尔兹海默病进行防治成为必然。海马区为实现学习、记忆和认知调节等功能提供了生理基础,与阿尔兹海默病的发生、发展密切相关。该区域存在成体神经发生现象,在某种意义上实现了大脑的可塑性,有望为阿尔兹海默病等神经退行性疾病的治疗开拓新的领域。本文从促进海马区成体神经发生的角度,提出了阿尔兹海默病的新的治疗方向,并总结了促成体神经发生药物的最新进展。
The pathogenesis of Alzheimer’s disease has not been elucidated. At present, the drugs used clinically can only be aimed at the corresponding symptoms and can not reverse the progression of the disease. Therefore, it is inevitable to adopt a new treatment strategy to prevent and treat Alzheimer’s disease. The hippocampus provides a physiological basis for functions such as learning, memory and cognitive regulation, and is closely related to the occurrence and development of Alzheimer’s disease. The presence of an adult neurogenesis in the area, in a sense, has resulted in the plasticity of the brain and is expected to open up new avenues for the treatment of neurodegenerative diseases such as Alzheimer’s disease. In this paper, we propose a new treatment direction for Alzheimer’s disease from the point of promoting adult neurogenesis in the hippocampus, and summarize the recent progress in promoting neurogenesis drugs.