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我校病毒性肝炎研究所郭树华等,采用D-氨基半乳糖纯种Wistar大白鼠中毒性肝炎模型,筛选防止肝细胞环死及促进肝细胞再生药物。以肝组织学改变、血清转氨酸及B-葡萄糖醛苷酸酶为指标,结果发现前列环素(PGI_2)能非常有效地保护D-氨基半乳糖所致的急性肝损伤(与稳定溶酶体有关),BSQ(PGI类似)及654-2(山菪碱)有中度保护作用,PGF07有轻微的保护作用,消炎痛可以减低BSQ的作用,BSQ对D-氨基半乳糖所致的急性肝损伤延迟给药无效。本文首于1985年日本第十一届急性肝不全治疗研究会上大会宣读,引起日本同行的广泛兴趣。
Guo Shuhua Institute of Viral Hepatitis, etc., using D-galactosamine pure Wistar rats toxic hepatitis model, screening to prevent hepatocyte death and promote liver cell regeneration drugs. Liver histology, serum alanine and B-glucuronidase as indicators, the results found that prostacyclin (PGI_2) can be very effective in the protection of D-galactosamine induced acute liver injury (with stable plasminogen Body-related), BSQ (similar to PGI) and 654-2 (anisodamine), PGF07 has a slight protective effect, indomethacin can reduce the effect of BSQ, and BSQ has an acute effect on D-galactosamine Delayed administration of liver injury is invalid. This article was first read at the General Assembly in Japan’s Eleventh Conference on Acute Hepatic Insufficiency Treatment in 1985, arousing widespread interest among Japanese counterparts.