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本文从血液动力学、血粘度、血象及形态学研究了24条狗内毒素休克发生机制。动物于注射内毒素(ET)后5分钟内血中即出现以血小板为主的微聚物,同时血中血小板、嗜中性白细胞、血压及中心静脉压均下降,血球压积增加,肺中出现微血栓,动物呈呼气性呼吸困难。此变化迅即缓解,动物于 ET 后30′～120′内上述指标逐渐部分恢复。4～6小时内血中又再度出现大量不易解聚的微聚物,上述指标变化加重而导致大部分动物于6小时内死亡,对照组无上述变化。此实验说明微聚物形成在内毒素休克发生中具有重要意义。
This paper studied the mechanism of endotoxin shock in 24 dogs from the aspects of hemodynamics, blood viscosity, blood images and morphology. Animals within five minutes after injection of endotoxin (ET) platelets in the blood that occurs in the main polymer, while blood platelets, neutrophils, blood pressure and central venous pressure decreased, hematocrit increased, the lung Thrombosis occurs, the animal was exhaled breathing difficulties. This change quickly ease, the animals in the ET after 30 ’~ 120’ part of the above indicators gradually restored. 4 to 6 hours again in the blood again a large number of non-easily depolymerized micro-polymer, the above indicators changed aggravate most of the animals died within 6 hours, the control group without the above changes. This experiment shows that the formation of micro-polymers in the occurrence of endotoxic shock is of great significance.