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【目的】探讨珍黄液治疗对支气管肺炎患儿可溶性细胞间黏附因子-1(sICAM-1)和C反应蛋白(CRP)的影响。【方法】采用半随机对照方法将60例支气管肺炎患儿分为对照组30例和观察组30例,对照组给予常规综合治疗,观察组在常规综合治疗的基础上加用珍黄液(由牛黄、珍珠层粉组成)口服。观察其临床综合疗效和治疗前后sICAM-1、CRP的水平变化。【结果】(1)观察组的总有效率为96.7%,对照组为53.3%,2组比较差异有统计学意义(P<0.05),表明观察组的临床综合疗效优于对照组。(2)治疗后观察组的sICAM-1及CRP水平均显著下降,与治疗前比较差异有统计学意义(P<0.05),与对照组治疗后比较,差异有统计学意义(P<0.05),表明观察组在改善患儿的sICAM-1及CRP指标方面作用优于对照组。【结论】珍黄液作为治疗小儿支气管肺炎的专方制剂疗效确切,对增强患儿自身免疫功能,减轻炎症反应有一定疗效。
【Objective】 To investigate the effects of Zhen Huang liquid on soluble intercellular adhesion molecule-1 (sICAM-1) and C-reactive protein (CRP) in children with bronchial pneumonia. 【Methods】 Sixty children with bronchopneumonia were divided into control group (n = 30) and observation group (n = 30) by semi-randomized control. The control group was given conventional comprehensive treatment. The observation group was treated with Zhen Huang liquid Bezoar, nacre composition) orally. To observe its clinical efficacy and treatment before and after sICAM-1, CRP level changes. 【Results】 (1) The total effective rate was 96.7% in the observation group and 53.3% in the control group. The difference between the two groups was statistically significant (P <0.05), indicating that the clinical efficacy of the observation group was better than that of the control group. (2) After treatment, the levels of sICAM-1 and CRP in the observation group were significantly decreased compared with those before treatment (P <0.05), and the difference was statistically significant (P <0.05) , Indicating that the observation group in improving sICAM-1 and CRP indicators in children better than the control group. 【Conclusion】 Zhen Huang liquid as a prescription for the treatment of children with bronchial pneumonia curative effect is exact, to enhance children’s autoimmune function, reduce inflammation have a certain effect.