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目的:探讨低密度脂蛋白胆固醇(LDL-C),超敏C反应蛋白(hs-CRP),单核细胞百分比在维吾尔族冠心病(CHD)患者诊断中的意义及其与冠脉病变严重程度的关系。方法:101例拟诊为CHD的维吾尔族患者,按冠脉造影(CAG)结果分为:冠心病(CHD)组(51例)和正常对照组(50例);冠心病组进一步分为:急性冠脉综合征(ACS)组(19例),稳定型心绞痛(SAP)组(32例);按冠脉病变分:单支血管病变组(23例),双支病变组(15例),多支病变组(13例);按冠脉狭窄程度分为:轻度(50%~74%)组(21例),中度(75%~94%)组(16例),重度(95%~100%)组(14例)。检测各组LDL-C,hs-CRP,单核细胞百分比并进行统计学分析。结果:与正常对照组相比,CHD组LDL-C[(1.836±0.864)mmol/L∶(3.482±0.901)mmol/L],hs-CRP[(5.128±5.853)mg/L∶(7.845±6.114)mg/L],单核细胞百分比[(6.304±2.513)%∶(10.102±2.861)%]水平明显升高(P<0.05~0.001),且SAP组、ACS组患者上述指标水平依次升高(P<0.05~0.001);LDL-C、hs-CRP、单核细胞百分比水平在单支病变组[(2.641±0.889)mmol/L,(6.615±6.44)mg/L,(6.884±2.315)%]、双支病变组[(3.843±0.943)mmol/L,(9.521±6.91)mg/L,(8.012±2.558)%]及多支血管病变组[(4.169±0.961)mmol/L,(10.634±7.561)mg/L,(9.154±2.984)%]患者中依次升高(P<0.05~0.001);上述指标在冠脉病变程度轻度组[(2.886±0.921)mmol/L,(6.574±6.541)mg/L,(6.787±2.255)%],中度组[(3.641±0.896)mmol/L,(9.438±7.641)mg/L,(8.156±2.645)%],重度组[(4.212±0.994)mmol/L,(10.984±8.012)mg/L,(9.354±2.991)%]也依次升高(P<0.05~0.001)。结论:维吾尔族患者外周血低密度脂蛋白胆固醇,超敏C反应蛋白,单核细胞百分比与冠心病的发生、发展有关,能反映冠状动脉病变程度和性质。
Objective: To investigate the significance of low density lipoprotein cholesterol (LDL-C), high-sensitivity C-reactive protein (hs-CRP) and monocyte percentage in the diagnosis of Uygur CHD patients and its relationship with the severity of coronary artery disease Relationship. Methods: 101 Uighur patients diagnosed as CHD were divided into coronary heart disease (CHD) group (51 cases) and normal control group (50 cases) by coronary angiography (CAG). The coronary heart disease group was further divided into: The patients in ACS group (19 cases) and SAP group (32 cases) were divided into two groups: coronary artery disease group (23 cases), double-vessel disease group (15 cases) , Multi-vessel disease group (13 cases). According to the severity of coronary artery stenosis, the severity of coronary artery stenosis was classified into mild (50% -74%) group (21 cases), moderate (75% 95% ~ 100%) group (14 cases). The LDL-C, hs-CRP and monocyte percentage of each group were detected and statistically analyzed. Results: Compared with the normal control group, the LDL-C [(1.836 ± 0.864) mmol / L: 3.482 ± 0.901 mmol / L] and hs-CRP [(5.128 ± 5.853) mg / L: 6.114) mg / L], the percentage of monocytes (6.304 ± 2.513)% (10.102 ± 2.861)% were significantly higher than those in SAP group and ACS group (P <0.05) (2.641 ± 0.889) mmol / L, (6.615 ± 6.44) mg / L, (6.884 ± 2.315)%, respectively in the single vessel disease group (P <0.05-0.001) ) And double-vessel disease group (3.843 ± 0.943 mmol / L, 9.521 ± 6.91 mg / L, 8.012 ± 2.558%, respectively) and multivessel disease group (4.169 ± 0.961 mmol / L, (10.634 ± 7.561) mg / L, (9.154 ± 2.984)%] in patients with mild coronary artery disease [(2.886 ± 0.921) mmol / L, 6.574 ± 6.541 mg / L, 6.787 ± 2.255%], moderate group (3.641 ± 0.896 mmol / L, 9.438 ± 7.641 mg / L, 8.156 ± 2.645% 4.212 ± 0.994 mmol / L, (10.984 ± 8.012) mg / L, (9.354 ± 2.991)%] also increased in turn (P <0.05-0.001). Conclusion: The levels of LDL-C, Hs-CRP and monocyte in peripheral blood of Uygur patients are related to the occurrence and development of coronary heart disease, which can reflect the extent and nature of coronary artery lesion.