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慢性炎症反应介导的免疫损伤在帕金森病等中枢神经变性疾病中扮演重要的角色,在此过程中,各种原因作 用下小胶质细胞的激活所产生的前炎症细胞因子和自由基启动或加重了多巴胺能神经元的损伤。以抑制小胶质细 胞激活为靶向的治疗方法将为帕金森病等神经变性疾病的治疗提供新的思路。
Chronic inflammatory response-mediated immune damage plays an important role in central nervous degenerative diseases such as Parkinson’s disease, during which priming of proinflammatory cytokines and free radicals by the activation of microglia under various causes Or aggravate dopaminergic neuron damage. Therapeutic approaches that target microglial activation will provide new insights into the treatment of neurodegenerative diseases such as Parkinson’s disease.