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目的 :探讨肾病综合征 (NS)患者血清中甲状腺激素水平的变化及临床意义。方法 :应用放射免疫法测定 18例原发性肾病综合征 (PNS)患者发作期和缓解期及 16例正常人血清甲状腺素水平。结果 :发作期血清T3 、T4水平显著低于缓解期及对照组(P <0 0 1)。结论 :NS患者存在甲状腺功能低下 ,缓解后恢复正常。这一状态可能是尿中大量蛋白丢失的结果。
Objective: To investigate the changes of serum thyroid hormone in patients with nephrotic syndrome (NS) and its clinical significance. Methods: The levels of serum thyroxine in 18 patients with essential nephrotic syndrome (PNS) at onset and remission and 16 normal subjects were measured by radioimmunoassay. Results: Serum levels of T3 and T4 were significantly lower than those in remission and control group (P <0.01). Conclusion: Patients with NS have hypothyroidism and return to normal after remission. This condition may be the result of a large amount of protein loss in the urine.