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目的探讨炔雌醇环丙孕酮片(达英-35)联合克罗米芬治疗多囊卵巢综合征(PCOS)并发不孕的临床疗效。方法 49例PCOS合并原发不孕患者随机分为治疗1组(23例)和治疗2组(26例)。治疗1组月经周期第5天直接使用克罗米芬促排卵;治疗2组先用达英-35治疗,连服21 d为1个周期,下一个月经周期第5天使用克罗米芬。观察两组临床效果。结果治疗1组周期排卵率64.3%,妊娠率13.0%;治疗2组周期排卵率83.3%,妊娠率42.3%,比较差异有统计学意义(P<0.05);治疗后治疗2组促黄体生成素(LH)、雌二醇(E_2)及睾酮(T)激素水平优于治疗1组(P<0.01)。结论达英-35联合克罗米芬治疗PCOS并发不孕效果明显,值得临床推广。
Objective To investigate the clinical efficacy of ethinylestradiol and cyproterone tablets combined with clomiphene in the treatment of infertility complicated with polycystic ovary syndrome (PCOS). Methods 49 cases of PCOS with primary infertility were randomly divided into treatment group 1 (23 cases) and treatment group 2 (26 cases). Treatment of a group of menstrual cycle 5 days directly with clomiphene and ovulation; treatment group 2 first with darling-35 treatment, and even served 21 d for a cycle, the next menstrual cycle clomiphene day 5. The clinical effects of two groups were observed. Results The ovulation rate of one group was 64.3% and the pregnancy rate was 13.0%. The ovulation rate of the two groups was 83.3% and the pregnancy rate was 42.3% (P <0.05). After treatment, two groups of luteinizing hormone (LH), estradiol (E2) and testosterone (T) hormone levels were better than those in treatment group 1 (P <0.01). Conclusion Da-Ying-35 combined with clomiphene in the treatment of PCOS complicated with infertility effect is worthy of clinical promotion.