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目的:探讨β-族溶血性链球菌(GBS)感染与胎膜早破的关系。方法:选择122例未足月胎膜早破(PPROM)孕妇的宫颈-阴道分泌物进行GBS培养,与同期的170例足月胎膜早破(PROM)孕妇和200例正常妊娠孕妇作对照,对GBS阳性的胎膜早破孕妇的羊水做白介素-6(IL-6)测定,并随机选择20例GBS阴性的胎膜早破孕妇作比较。结果:PPROM孕妇宫颈-阴道分泌物GBS阳性率(17.2%)明显高于PROM(11.8%)和正常组(6.0%)(P<0.05),GBS阳性的胎膜早破孕妇羊水IL-6(176.6±82.4)ng/L明显高于GBS阴性的胎膜早破孕妇(122.7±59.3)ng/L(P<0.05)。结论:GBS感染可引起胎膜早破的发生。
Objective: To investigate the relationship between β-hemolytic streptococcus (GBS) infection and premature rupture of membranes. Methods: The cervix - vaginal secretions of 122 pregnant women with incomplete premature rupture of membranes (PPROM) were selected for GBS culture. Compared with 170 full-term PROM pregnant women and 200 normal pregnant women, Interleukin-6 (IL-6) was measured in amniotic fluid of pregnant women with GBS-positive premature rupture of membranes and 20 pregnant women with GBS-negative premature rupture of membranes were randomly selected. Results: The positive rate of GBS in cervicovaginal secretions of PPROM pregnant women (17.2%) was significantly higher than PROM (11.8%) and normal controls (6.0%) (P <0.05) 176.6 ± 82.4 ng / L was significantly higher than that of GBS negative pregnant women with premature rupture of membranes (122.7 ± 59.3) ng / L (P <0.05). Conclusion: GBS infection can cause premature rupture of membranes.