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目的探讨三维适形放疗对原发性肝癌合并门静脉癌栓患者近期疗效及生存状况的影响。方法选择原发性肝癌合并门静脉癌栓患者72例,根据治疗方法将其分为观察组与对照组,每组36例。对照组采用经导管肝动脉栓塞化疗(TACE)疗法,观察组采用TACE+三维适形放疗治疗。随访1年,比较两组近期疗效、生存状况及不良反应。结果观察组近期疗效优于对照组,差异有统计学意义(P<0.05);治疗后,两组生活质量评分明显升高,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组1年生存率高于对照组,差异有统计学意义(P<0.05)。结论三维适形放疗治疗原发性肝癌合并门静脉癌栓能提高患者近期疗效,改善患者生活质量,延长患者生存时间。
Objective To investigate the effect of three-dimensional conformal radiotherapy on the curative effect and survival of patients with primary hepatocellular carcinoma and portal vein tumor thrombus. Methods Seventy-two patients with primary hepatocellular carcinoma and portal vein tumor thrombus were divided into observation group and control group according to the treatment method, with 36 cases in each group. The control group received transcatheter hepatic arterial chemoembolization (TACE) and the observation group received TACE + three-dimensional conformal radiotherapy. Follow up for 1 year, compared the two groups of short-term efficacy, survival and adverse reactions. Results The curative effect in the observation group was better than that in the control group (P <0.05). After treatment, the quality of life scores of the two groups were significantly increased, and the observation group was higher than the control group, the difference was statistically significant (P <0.05 ). The 1-year survival rate of the observation group was higher than that of the control group, with significant difference (P <0.05). Conclusion Three-dimensional conformal radiotherapy for primary hepatocellular carcinoma with portal vein tumor thrombus can improve the short-term efficacy, improve the quality of life of patients and extend the survival time of patients.