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作者的最近实验显示,在正常周期妇女的卵泡中期,注射轭合雌激素32小时后,尽管LH显著降低,但血浆免疫活性LHRH水平仍无变化。这说明雌激素对正常周期妇女促性腺激素分泌的负反馈作用是降低垂体对LHRH的反应性,不改变下丘脑的LHRH的释放。本文的目的在于研究雌激素对人类促性腺激素分泌的负反馈作用是否是对垂体的直接作用。 6例正常月经妇女,年龄21～23岁,周期27～32天,在卵泡中期,静脉注射20mg轭合的雌激素(Premarin)前2小时和后8小时,静注2.5μg人工合成LHRH,用放射免疫法测定LH和FSH。实验结果显示:注射雌激素前、后血浆FSH
Recent author’s experiments showed that plasma immunoreactive LHRH levels remained unchanged in 32 folds of mid-follicular phase in normal-cycle women despite a significant decrease in LH. This shows that estrogen on normal cycle women’s gonadotropin secretion negative feedback effect is to reduce the pituitary LHRH reactivity, does not change the LHRH release of the hypothalamus. The purpose of this article is to investigate whether the negative feedback of estrogen on human gonadotropin secretion is a direct effect on the pituitary gland. 6 normal menstruating women, aged 21 to 23 years and 27 to 32 days. Intravenous injection of 2.5 μg of synthetic LHRH two and eight hours after the intravenous injection of 20 mg of conjugated premarin Radioimmunoassay for the determination of LH and FSH. The experimental results show: before and after injection of estrogen plasma FSH