山莨菪碱慢性给药对自发性高血压大鼠主动脉功能及形态的影响

• 作 者: 王烈 郭敬 陈红 钟梅芳 黎成金
• 机 构: 南京军区福州总医院普通外科研究所,上海交通大学医学院药理教研室,上海医药高等专科学校基础部,
• 出 处: 福州总医院学报
• 发表日期: 2010年01期
• 关键词: 自发性高血压 大鼠主动脉 莨菪碱 药对 血压变化情况 原发性高血压 舒张反应 内皮细胞 大鼠血压 离体血管

血管内皮功能受损与自发性高血压发病密切相关。近年有人研究发现原发性高血压患者舒张压、脉压升高与平滑肌Kca通道特性改变有密切关系[1]。以内皮及平滑肌细胞特异性受体为靶标,纠正内皮细胞功能紊乱和病理学改变,维持其生理功能,是降低血压及维持血管内皮形态与功能的理想策

Vascular endothelial dysfunction and the incidence of spontaneous hypertension are closely related. In recent years, some studies have found that patients with essential hypertension, diastolic blood pressure, elevated pulse pressure and smooth muscle Kca channel characteristics are closely related [1]. Endothelial and smooth muscle cell-specific receptors as the target, to correct endothelial dysfunction and pathological changes and maintain their physiological function, is to reduce blood pressure and maintain vascular endothelial morphology and function of the ideal