Synthesis, Characterization and Antimicrobial Study of a New Schiff Base Paeonol-phenylpropanolamine

• 作 者: 许同桃 许兴友 高健 刘兰蕾 倪帅帅 陆路德 杨绪杰
• 机 构: Department of Chemical Engineering Huaihai Institute of Technology,Department of Chemical Engineeri
• 出 处: 结构化学
• 发表日期: 2006年12期
• 关键词: Schiff methanol aromatic ingredient pumilus refined congestion absolute listed D

A novel Schiff base compound was synthesized by the reaction of paeonol and phenylpropanolamine in absolute methanol. It was characterized by elemental analyses, IR, 1H NMR and X-ray single-crystal diffraction. The compound crystallizes in the triclinic system, space group P1, with a = 6.4075(11), b = 10.2821(18), c = 12.573(2) ·, α = 92.606(3), β = 100.980(3), γ = 90.994(3)°, V = 812.1(2) ·3, Mr = 299.36, Z = 2, F(000) = 320, Dc = 1.224 g/cm3, T = 293(2) K, μ = 0.083 mm-1 and λ = 0.71073 ·, the final R = 0.0555 and wR = 0.1619 for 2442 observed reflections with I > 2σ(I). The compound was valued for its antimicrobial activity against bacterial strands using the agar diffusion method. It is found to be active against Candida albicans and Staphylococcus aureus.

A novel Schiff base compound was synthesized by the reaction of paeonol and phenylpropanolamine in absolute methanol. It was characterized by elemental analyzes, IR, 1H NMR and X-ray single-crystal diffraction. The compound crystallizes in the triclinic system, space group P1, with a = 6.4075 (11), b = 10.2821 (18), c = 12.573 (2) ·, α = 92.606 (3), β = 100.980 (3), γ = 90.994 ) 3, Mr = 299.36, Z = 2, F (000) = 320, Dc = 1.224 g / cm3, T = 293 (2) K, μ = 0.083 mm-1 and λ = 0.71073 ·, final R = 0.0555 and wR = 0.1619 for 2442 observed reflections with I> 2σ (I). The compound was valued for its antimicrobial activity against bacterial strands using the agar diffusion method. It is found to be active against Candida albicans and Staphylococcus aureus.