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实验用雄性大鼠，玻璃微电极细胞外记录Ｔ１２－Ｌ１脊髓背角会聚神经元对后爪伤害性刺激的反应，观察到低强度（２Ｖ）电针作用于与痛源接近的“足三里”穴对背角神经元的伤害性反应有明显的抑制作用，而远隔穴位“下关”穴则无效。而当采用超过Ｃ类纤维阈值１８Ｖ电针时，则远隔穴位“下关”也有明显的镇痛作用。表现为强电针穴位镇痛作用的广泛性。而损毁ＮＲＭ后，强电针（１８Ｖ）远节段“下关”穴的镇痛作用消失，而近节段“足三里”穴无论是强（１８Ｖ）或弱（２Ｖ）电针，仍有明显的镇痛作用，但此效应也被削弱，这表明远节段“下关”强电针的镇痛作用的广泛性可能主要由伤害性刺激通过脊髓上ＮＲＭ痛负反馈调制机制实现的。而２Ｖ电针近节段穴位的镇痛作用可能主要是通过脊髓镇痛机制实现的，但也有脊髓上镇痛机制参与。
Experimental male rats, glass microelectrode extracellular recording T12-L1 spinal dorsal horn convergent neurons on the hind paw nociception in response to the observed low-intensity (2V) electroacupuncture effect and pain near the “Zusanli” Point on the dorsal horn neurons nociceptive response was significantly inhibited, while the distant points “Shimonoseki” point is invalid. And when using more than C fiber threshold 18V electro-acupuncture, then the acupuncture points “off” has obvious analgesic effect. The performance of the strong electro-acupoint analgesia broad. However, after NRM was destroyed, the analgesic effect of the “Shangguan” acupuncture at the distal segment of strong electro-acupuncture (18V) disappeared, while the acupoints at Zusanli of the proximal segment both had strong (18V) or weak (2V) electroacupuncture Obvious analgesic effect, but this effect is also weakened, which indicates that the broad analgesic effect of the strong electro-acupuncture at the distal segment may be mainly caused by the nociceptive stimulation through the negative feedback modulation mechanism of NRM on the spinal cord. However, the analgesic effect of 2V electroacupuncture near the acupoints may be mainly through the spinal analgesia mechanism, but there is also the spinal cord analgesia mechanism involved.