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Non-melanoma skin cancer (NMSC) is one of the most common cancers in the US, although the role of obesity inskin cancer remains unclear. In vivo studies have consistently demonstrated that obese mice challenged with UVB radiation showincreased skin tumorigenesis in comparison with leaner control mice. Growing evidence suggests that enhanced inflammation,oxidative stress and impaired apoptosis may play important roles in the development of skin cancer. Interventions such as voluntaryexercise and the surgical removal of parametrial fat have been demonstrated to be effective in reducing adipose tissue that mayinfluence the development of skin cancer; however, these interventions are not achievable in all obese patients. Therefore, the useof dietary natural phytochemicals that may modify and reverse the deregulated molecular and epigenetic events related to obesityand cancer development might represent a potential therapeutic modality due to their potential efficacy and low toxicity. In thisreview, we aim to provide the molecular and epigenetic basis of the NMSC-obesity relationship and to highlight the potentialanti-cancer chemopreventive benefits of dietary phytochemicals such as sulforaphane and epigallocatechin-3-gallate.
Non-melanoma skin cancer (NMSC) is one of the most common cancers in the US, although the role of obesity inskin cancer remains unclear. In vivo studies have consistently verified that obese mice challenged with UVB radiation showincreased skin tumorigenesis in comparison with leaner control mice. Growing evidence suggests that enhanced inflammation, oxidative stress and impaired apoptosis may play important roles in the development of skin cancer. Interventions such as voluntary exercise and the surgical removal of parametrial fat have been demonstrated to be effective in reducing adipose tissue that mayinfluence the development of the use of dietary natural phytochemicals that may modify and reverse the deregulated molecular and epigenetic events related to obesity and cancer development might represent a potential therapeutic modality due to their potential efficacy and low toxicity. In th isreview, we aim to provide the molecular and epigenetic basis of the NMSC-obesity relationship and to highlight the potentiating-cancer chemopreventive benefits of dietary phytochemicals such as sulforaphane and epigallocatechin-3-gallate.