【摘 要】
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To the Editor:rnHepatocellular carcinoma (HCC) is one of the most common cancers worldwide [ 1 , 2 ]. Portal vein tumor thrombus (PVTT) has been demonstrated to be a poor prognostic indicator for HCC [3–5] . However, effective treatment for the condition
【机 构】
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Department of Hepatic Surgery VI,Eastern Hepatobiliary Surgery Hospital,Second Military Medical Univ
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To the Editor:rnHepatocellular carcinoma (HCC) is one of the most common cancers worldwide [ 1 , 2 ]. Portal vein tumor thrombus (PVTT) has been demonstrated to be a poor prognostic indicator for HCC [3–5] . However, effective treatment for the condition is still limited. Un- derstanding the insight into the molecular mechanisms behind PVTT development may help to establish a new therapeutic strat- egy. Animal models which mimic the development of PVTT in humans are necessary to figure out the molecular mechanisms behind PVTT development. Currently, a wide range of animal models have been established for HCC from different angles, in- cluding chemically-induced models like diethylnitrosamine, car- bon tetrachloride, thioacetamide, and phenobarbital, genetically- engineered mouse (GEM) models like Wnt/ β-catenin signaling pathway (CTNNB1), telomerase reverse transcriptase (TERT) activa- tion, aflatoxin B1 and HBV infection, and engrafted models [6–8] . However, all the above animal models cannot be used in the study of PVTT, since these models were not able to present all the histo- logical, physiological, and clinical features of human PVTT.
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