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机体所摄取的药物必须在特定部位达到一定浓度后才发挥药效作用,而药物在作用部位的浓度不仅与给药剂量相关,更是与药物在机体内的吸收、分布、代谢和排泄过程密切相关。由于在病理状态下机体组织器官发生不同程度的病变,生理功能有别于正常组织器官,因此病变机体的药物体内行为可能发生显著改变,故研究机体病理状态下的药代动力学,对于临床合理设计给药方案具有重要意义。通过分析一些临床常见疾病因素对中药药物吸收、分布、代谢和排泄各环节的影响,探讨不同的机体病变及其交互作用对中药体内代谢过程的影响,为中药及其相关制剂的临床合理用药提供一定参考。
Drugs ingested by the body must exert pharmacodynamic effects after reaching a certain concentration in a specific site, and the concentration of the drug at the site of action is not only related to the dose administered but also closely related to the absorption, distribution, metabolism and excretion of drugs in the body Related. Because pathological conditions in the body tissues and organs of varying degrees of disease, the physiological function is different from normal tissues and organs, the pathological changes in the behavior of the body of drugs may change significantly, so the study of the body pathological pharmacokinetics, for clinical reasonable Designing dosing regimens is of great importance. By analyzing the impact of some common clinical disease factors on the absorption, distribution, metabolism and excretion of traditional Chinese medicine, the effects of different pathological changes and their interactions on the metabolic process of traditional Chinese medicine (TCM) were explored to provide clinical rational medicine for traditional Chinese medicine and its related preparations Certain reference.