论文部分内容阅读
Aim:Clonidine is an α_2 adrenoceptor agonist that is frequently used to reducewithdrawal symptoms during opioid detoxification in humans.The long-termeffects of clonidine on withdrawal symptoms and its effects on subsequent drugexposure have not been thoroughly documented.The aim of the study was todetermine if clonidine administered during morphine withdrawal in rhesus mon-keys produces long-lasting effects on withdrawal symptoms and alters the effectsof subsequently taken drugs of abuse.Methods:Adult male rhesus monkeyswere treated with increasing doses of morphine for 90 d to induce opiate (narcotic)dependence.The immediate and long-lasting effects of 1 week’s administration ofclonidine were measured via the recording of morphine withdrawal signs and thesubsequent effects of challenge injections of morphine or cocaine.Results:Monkeys chronically treated with morphine displayed withdrawal signs that lasted2 weeks after cessation of morphine administration and displayed sensitized re-sponses to subsequent morphine and cocaine injections.Clonidine significantlyreduced certain morphine withdrawal signs and overall withdrawal score,but theseeffects did not persist upon cessation of clonidine treatment.Sensitization to theeffects of morphine and cocaine were significantly reduced in monkeys previ-ously treated with clonidine.Conclusion:Our results suggest that in addition toits short-term alleviating effect on morphine withdrawal signs,clonidine may re-duce subsequent effects of drugs of abuse after prolonged abstinence.
Aim: Clonidine is an α_2 adrenoceptor agonist that is frequently used to reduce withdrawal symptoms during opioid detoxification in humans. Long-term effects of clonidine on withdrawal symptoms and its effects on subsequent drugexposure have not been honored documented. The aim of the study was todetermine if clonidine administered during morphine withdrawal in rhesus mon-keys produces long-lasting effects on withdrawal symptoms and alters the effects of subsequent taken drugs of abuse. Methods: Male male rhesus monkeyswere treated with increasing doses of morphine for 90 d to induce opiate (narcotic) dependence The immediate and long-lasting effects of 1 week’s administration of clonidine were measured via the recording of morphine withdrawal signs and the subsequent effects of challenge injections of morphine or cocaine. Results: Monkeys chronically treated with morphine displayed withdrawal signs that lasted 2 weeks after cessation of morphine administration and displayed sensitized re -sponses to subsequent morphine and cocaine injections. Clonidine significantlyreduced certain morphine withdrawal signs and overall withdrawal score, but these effects did not persist upon cessation of clonidine treatment. Sensitization to the effects of morphine and cocaine were significantly reduced in monkeys previ-ously treated with clonidine. Conclusion: Our results suggest that in addition to short to term alleviating effect on morphine withdrawal signs, clonidine may re-duce subsequent effects of drugs of abuse after prolonged abstinence.