Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multid

• 作 者: Zhi-WeiYu PengZhao MingLiu Xin
• 机 构: DepartmentofAbdominalSurgery,DepartmentofGeneralSurgery,DepartmentofGeneralSurgery,DepartmentofGeria
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2004年13期
• 关键词: 反向作用 5-氟 抵抗力 腺病毒 调节作用 基因表达 野生型 P53基因 多药炕药性 结肠癌 肿瘤 LoVo/5-FU

AIM: To observe the reversal effects of wide-type p53 gene on multi-drug resistance to 5-FU (LOVO/5-FU).METHODS: After treatment with Ad-p53, LOVO/5-FU sensitivity to 5-Fu was investigated using tetrazolium dye assay. Multidrug resistance gene-1 (MDR1) ge