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旋毛虫(Trichinella spiralis)及其衍生抗原可通过诱导树突状细胞(DC)的半成熟来刺激T细胞的活化,从而调节Th1/Th2型细胞的免疫应答,以缓解或抑制过敏性疾病/自身免疫性疾病。在此免疫调节过程中,调节性T细胞(Treg)及抑炎细胞因子的释放发挥着重要作用。本文综述了旋毛虫及其衍生产物在各种免疫失调性疾病中的调节作用及其机制。
Trichinella spiralis and its derived antigens can stimulate the activation of T cells by inducing the maturation of dendritic cells (DCs) and thereby regulate the immune response of Th1 / Th2 type cells to alleviate or inhibit allergic diseases / themselves Immune disease. In this process of immune regulation, regulatory T cells (Tregs) and anti-inflammatory cytokines play an important role. This article reviews the regulatory role of Trichinella spiralis and its derivatives in various immune disorders and their mechanisms.