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目的和方法：在培养的家兔血管平滑肌细胞上，观察了肾上腺髓质素（Ａｄｍ）对溶血磷脂酸（ＬＰＡ）诱导的ＤＮＡ合成和丝裂素活化蛋白激酶（ＭＡＰＫ）活性途径激活的影响。结果：ＬＰＡ使［３Ｈ］－ＴｄＲ掺入和ＭＡＰＫ活性增加，Ａｄｍ对基础水平的ＭＡＰＫ活性和［３Ｈ］－ＴｄＲ的掺入并无显著影响，但Ａｄｍ对ＬＰＡ刺激［３Ｈ］－ＴｄＲ掺入和ＭＡＰＫ活性具有抑制作用。结论：Ａｄｍ和ＬＰＡ相互作用参与血管平滑肌细胞增殖的调节。
PURPOSE AND METHODS: The effects of adrenomedullin (Adm) on lysophosphatidic acid (LPA) -induced DNA synthesis and activation of the mitogen-activated protein kinase (MAPK) pathway were observed in cultured rabbit vascular smooth muscle cells. Results: [3H] -TdR incorporation and MAPK activity increased with LPA. Adm had no significant effect on basal levels of MAPK activity and incorporation of [3H] -TdR, but Adm did not affect [3H] -TdR incorporation and MAPK activity has an inhibitory effect. Conclusion: The interaction between Adm and LPA is involved in the regulation of vascular smooth muscle cell proliferation.