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我科于1981年收治一例急性再生障性贫血(以下简称急再障)发病前四月曾服用甲氰咪胍治疗溃疡病。考虑到甲氰咪胍与再障发病有关而类似病例尚未见报告,现整理报道如下: 患者刘××,女性,34岁,干部。五年前经上消化道钡餐检查证实为十二指肠球部溃疡,长期治疗不愈。四月前服用甲氰咪胍,每日三次,每次400毫克,共用药两月余,总剂量为96克。服甲氰咪胍后约50天出现疲困感,未引起注意。停药后30多天有低热、体温38℃以下,并相继出现头昏、皮肤出血点。在本单位职工医院查Hb6g%,WBC1000/mm~3,PC低(数值不详),骨髓检查符合“再障”。收住院20多天,应用多种抗菌素抗感染、输血
My Section in 1981 admitted to a case of acute aplastic anemia (hereinafter referred to as acute aplastic anemia) before the onset of April had taken cimetidine treatment of ulcer disease. Considering that cimetidine is related to the incidence of aplastic anemia and similar cases have not been reported, the reports are as follows: Patient Liu XX, female, 34 years old, cadre. Five years ago by the upper gastrointestinal barium meal examination confirmed duodenal ulcer, long-term treatment of unhealed. Take cimetidine four months ago, three times a day, each 400 mg, more than two months medication, the total dose of 96 grams. Cimetidine after about 50 days of fatigue, did not pay attention. More than 30 days after stopping fever, body temperature below 38 ℃, and have dizziness, skin bleeding point. Hb6g%, WBC1000 / mm ~ 3, low PC (unknown value) in the staff and workers of the unit, bone marrow examination in line with “aplastic anemia”. Admitted to hospital for more than 20 days, the application of a variety of anti-infective antibiotics, blood transfusion