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Akita县Kosaka镇9个行政区的土壤被一炼铜厂的含镉排放物污染。70年代中期从Ko—saka镇居住区镉排放物的几何均数为146μg/d,约相当于对照居住区的3.6倍(41μg/d)。1975～1977年对其中一行政区115名年龄>40岁的居民和其他8个行政区115名70～79岁的居民做过流行病学调查。1990年8月对230名对象作了死亡情况调查、观察期为最初的检查日期到死亡、调离日期或1990年8月1日止,进入队列的230名研究对象,88名死亡、3名调离研究地区,总观察人年为2700.7。研究人群的男性平均年龄是61.9岁(标准差为11.8),女性为63.5岁(标准差为12.7),男性尿β_2—微球蛋白(β_2—m)浓度的几何均数是
Soil in nine districts of Kosaka town in Akita County is contaminated with cadmium-containing emissions from a copper refinery. The geometric mean of cadmium emissions from residential areas in the town of Ko-saka in the mid-1970s was 146 μg / d, equivalent to 3.6 times (41 μg / d) the control residential area. From 1975 to 1977, 115 residents aged 40 and over in one administrative region and 115 residents aged 70 to 79 in eight other administrative regions were surveyed. In August 1990, 230 persons were investigated for death from the initial examination date to the date of death, removal from school or as of 1 August 1990, of the 230 subjects enrolled in the cohort, 88 dead, 3 Transfer away from the research area, the total observed person-year is 2700.7. The average age of men in the study population was 61.9 years (with a standard deviation of 11.8) and 63.5 years in women (with a standard deviation of 12.7). The geometric mean urinary β_2-microglobulin (β_2-m) concentration in the study population was