【摘 要】
：
When considering disease etiology, we need to view the role of the environment along the continuum from health to disease for individuals because we know that
【机 构】
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National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle
论文部分内容阅读
When considering disease etiology, we need to view the role of the environment along the continuum from health to disease for individuals because we know that there are complex interactions between genes, their molecular expression, and environmental factors over a person’s lifetime. We clearly have huge gaps in our knowledge along this continuum, and these gaps are natural opportunities for research. There are many factors to consider as we assess the relationship between environmental exposures over a lifetime. One factor is persistence of chemicals that live beyond their initial intended use. Another factor is the fact that inert ingredients are not really inert. Low dose is also another consideration. We need to understand the biological effect of low dose exposure and we should clearly define what they mean by low dose research. For example, are we measuring the administered dose, or the intal/circulating dose?
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