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急性白血病和恶性淋巴瘤的病人,由于肿瘤细胞的溶解可以发生高尿酸血症,高磷酸血症、高血钾、低血钙等代谢紊乱,谓之急性肿瘤溶解综合征(简称 ATLS)。Burkitt 淋巴瘤的病人瘤细胞增殖比较快,而且化疗后迅速溶解,代谢紊乱特别严重,可以导致肾功能衰竭和突然死于高血钾或低钙。作者报道了用常用方案治疗37例 Burkitt 淋巴瘤所引起的肿瘤溶解综合征的特点。
Acute leukemia and malignant lymphoma patients, due to the dissolution of tumor cells can occur hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia and other metabolic disorders, that the acute tumor lysis syndrome (ATLS). Burkitt lymphoma patients with rapid proliferation of tumor cells, but also rapidly dissolved after chemotherapy, metabolic disorders are particularly serious, can lead to renal failure and sudden death from hyperkalemia or hypocalcemia. The authors report the characteristics of the tumor lysis syndrome caused by the treatment of 37 Burkitt’s lymphomas with commonly used regimens.