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目的对急性心源性肺水肿患者血浆N末端脑钠肽(NT-proBNP)及脑钠肽(proBNP)浓度进行比较,探讨NT-proBNP对急性心源性肺水肿的诊断价值。方法分别应用电化学发光免疫分析技术和微粒子酶联免疫法测定85例心力衰竭患者和70例对照组血清NT-proBNP及proBNP水平,并使用受试者ROC曲线分析两者诊断效能。结果急性心源性肺水肿组患者血浆NT-proBNP及proBNP水平均较对照组明显升高,差异均有统计学差异(P<0.01或<0.05);受试者ROC曲线分析显示两者NT-proBNP诊断效能包括特异性、敏感性、阳性预测值、阴性预测值、准确性均高于proBNP。结论急性心源性肺水肿患者血浆NT-proBNP及proBNP浓度均升高,因此两者对急性心源性肺水肿有一定的诊断价值,而NT-proBNP是一个更为敏感的生化指标。
Objective To compare the plasma concentrations of NT-proBNP and proBNP in patients with acute cardiogenic pulmonary edema and to investigate the diagnostic value of NT-proBNP in acute cardiogenic pulmonary edema. Methods Serum levels of NT-proBNP and proBNP in 85 patients with heart failure and 70 controls were determined by electrochemiluminescence immunoassay and microparticle enzyme-linked immunosorbent assay (ELISA) respectively. The diagnostic efficacy of the two methods was analyzed by ROC curve. Results The plasma levels of NT-proBNP and proBNP in patients with acute cardiogenic pulmonary edema were significantly higher than those in the control group (P <0.01 or <0.05). The ROC curves of the subjects showed that NT- ProBNP diagnostic efficacy, including specificity, sensitivity, positive predictive value, negative predictive value, accuracy are higher than proBNP. Conclusion The plasma levels of NT-proBNP and proBNP are elevated in patients with acute cardiogenic pulmonary edema. Therefore, both of them have certain diagnostic value in acute cardiogenic pulmonary edema, and NT-proBNP is a more sensitive biochemical indicator.