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目的研究振动性白指患者的自主神经系统对冷刺激的反应。方法２２名振动性白指患者（ＶＷＦ组）及１９名正常对照（对照组）进行了局部冷水刺激实验，记录受试者的心电信号，实验后将记录的心电信号通过处理转化为ＲＲ间期信号，然后对这些ＲＲ间期信号进行功率谱分析，计算标准化的ＬＦ（０．０２～０．１５Ｈｚ）功量（ＬＦ％），标准化的ＨＦ（０．１５～０．４０Ｈｚ）功量（ＨＦ％），以及ＬＦ／ＨＦ比率。结果冷暴露开始后，ＶＷＦ组及对照组的ＨＦ％与暴露前的水平相比都有显著下降，ＶＷＦ组的ＬＦ／ＨＦ比率与暴露前的水平相比有显著增大，而且冷暴露中ＶＷＦ组的ＬＦ／ＨＦ比率显著高于对照组的相应的ＬＦ／ＨＦ比率。结论冷刺激导致ＶＷＦ组和对照组的副交感神经活动减弱，但对照组还能保持交感与副交感的平衡，而ＶＷＦ组却不能保持两者平衡，交感神经活动明显占优，冷刺激中ＶＷＦ组ＬＦ／ＨＦ比率明显高于对照组的ＬＦ／ＨＦ比率说明振动性白指患者的交感神经系统对冷刺激可能存在过敏反应。
Aim To study the response of patients with autonomic nervous system to cold stimulation in sham white. Methods Local cold water stimulation was performed in 22 VWF patients and 19 normal controls (control group). ECG signals of the subjects were recorded. After the experiment, the recorded ECG signals were converted to R R interval signal, and then power spectrum analysis of these RR interval signal to calculate the normalized LF (0.02 ~ 0.15Hz) power (LF%), normalized HF (0.15 ~ 0. 40Hz) power (HF%), and LF / HF ratio. Results After cold exposure started, the HF% of VWF group and control group decreased significantly compared with that before exposure. The LF / HF ratio of VWF group increased significantly compared with that before exposure, and the VWF of cold exposure The LF / HF ratio of the group was significantly higher than the corresponding LF / HF ratio of the control group. Conclusion Cold stimulation can reduce the parasympathetic activity of VWF group and control group, while the control group can maintain the balance of sympathetic and parasympathetic tone. However, VWF group can not maintain the balance between the two. Sympathetic activity obviously dominates. Cold stimulation of VWF group LF / HF ratio was significantly higher than that of the control group LF / HF ratio shows that white patients with sympathetic nervous system may have an allergic reaction to cold stimulation.