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目的:探讨血清降钙素原(PCT)与婴幼儿社区获得性肺炎病情严重程度相关性以及病原学鉴别、指导抗生素使用的临床价值。方法:对86例婴幼儿社区获得性肺炎患儿,依据重症肺炎诊断标准,分为重症肺炎22例,轻症肺炎64例,采用电化学发光免疫分析检测血清PCT,采用免疫比浊法检测血清超敏C反应蛋白(CRP),同时进行病原学检测。结果:28例细菌性肺炎患儿PCT、CRP的值明显高于非细菌性感染患儿,且PCT第1天的值明显升高,随着抗生素使用至第3天明显下降,至第7天基本降至正常。而CRP在细菌性肺炎患儿中,第1天仅升高不明显,至第3天明显升高,随着抗生素使用,逐渐下降,持续时间较长。结论:PCT及CRP均可作为细菌性肺炎诊断重要依据,但PCT相比CRP,在细菌性肺炎中敏感性、特异性更高,可作为早期诊断依据,对指导抗生素的应用及疗效评价有重要临床价值。
Objective: To investigate the clinical significance of the correlation between serum procalcitonin (PCT) and the severity of community-acquired pneumonia in infants and young children, as well as the etiological identification and antibiotic use. Methods: Eighty-six infants with community-acquired pneumonia were divided into severe pneumonia (22 cases) and mild pneumonia (64 cases) according to the diagnostic criteria of severe pneumonia. The serum PCT was detected by electrochemiluminescence immunoassay and serum was detected by immunoturbidimetry High-sensitivity C-reactive protein (CRP), simultaneous etiological testing. Results: The values of PCT and CRP in 28 cases of children with bacterial pneumonia were significantly higher than those of children without bacterial infection, and the value of PCT on the first day was significantly increased. The antibiotics decreased significantly on the third day and reached the seventh day Basically down to normal. The CRP in children with bacterial pneumonia increased only on the first day was not obvious until the first 3 days increased significantly with the use of antibiotics, gradually decreased for a long time. Conclusion: Both PCT and CRP can be used as an important basis for the diagnosis of bacterial pneumonia. However, compared with CRP, PCT is more sensitive and specific in bacterial pneumonia and can be used as an early diagnosis basis. It is important to guide the application of antibiotics and evaluation of the curative effect Clinical Value.