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目的 :探讨不同剂量的妇异通冲剂对因琼脂所致大鼠肿胀及大鼠棉球肉芽组织增生的影响 ;方法 :给大鼠灌服不同药物 ,每日一次 ,连续 5天 ,于第 5天灌药后 30分钟给大鼠右后肢足趾皮下注射 1%琼脂溶液0 0 5ml,致炎后 1、3、5、2 4小时测量足趾关节的周长变化 ,以左侧足对照 ,左右周长之差为肿胀炎症程度。观察在乙醚麻醉下将 30mg重消毒棉球在无菌操作下植入大鼠蹊部皮下 ,每侧 1只 ,术后灌服不同药物 ,每日一次 ,连续8天于第 8天灌药后 2小时处死动物 ,剥离皮下棉球肉芽肿比较给药组与对照组的差异 ;结果 :妇异通三个剂量组对大鼠肿胀的趾关节均有明显抑制作用。
OBJECTIVE: To investigate the effects of different doses of Fu Yi Tong Granules on agar-induced rat swelling and rat cotton granulation tissue proliferation; Method: Rats were given different drugs once daily for 5 days in the 5th 30 minutes after the injection, the rat’s right hindlimb was injected subcutaneously with 1% agar solution at 0 to 5 ml, and the changes in the circumference of the toe joint were measured at 1, 3, 5, and 24 hours after inflammation. The difference between the left and right perimeters is the degree of swelling and inflammation. Observe that under sterile anesthesia 30 mg sterilized cotton balls were implanted subcutaneously on the ankles of rats, one on each side, and each drug was administered orally once a day for 8 days on the 8th day. Animals were sacrificed in hours and the subcutaneous tamponade granuloma was peeled off. The difference between the administration group and the control group was observed. Results: The three doses of Futongtong had significant inhibitory effects on the swollen toe joints of rats.